کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
408540 | 679031 | 2007 | 6 صفحه PDF | دانلود رایگان |

We simulate the induction and maintenance of late long-term potentiation (L-LTP) in the hippocampal dentate gyrus by means of a new synaptic plasticity rule that is the result of combination of the spike-timing-dependent plasticity (STDP) and the moving LTD/LTP threshold θM from the Bienenstock, Cooper and Munro (BCM) theory of synaptic plasticity. We propose the activity-dependent functional equation for θM to be based on two processes: (1) fast process that depends on average postsynaptic spike count and (2) slow process that is a function of concentration of phosphorylated CREB (cAMP-responsive element binding) transcription factor, activation of which induces gene expression to maintain L-LTP. In the end, we propose a new, more general form of synaptic plasticity rule, which is applicable to any form of activity-dependent synaptic plasticity.
Journal: Neurocomputing - Volume 70, Issues 10–12, June 2007, Pages 2035–2040