کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4103815 | 1605253 | 2012 | 5 صفحه PDF | دانلود رایگان |
IntroductionApproximately 1 of 4 patients with osteoradionecrosis (ORN) of the mandible develop ongoing disease despite extensive mandible resection to margins determined by the presence of bleeding bone at the time of surgery.ObjectiveTo determine whether pathologic examination of bony margins in assessing for the presence of necrotic edges is correlated with ongoing ORN.MethodsResected mandible specimens from 34 patients with severe mandibular ORN were examined histologically for the presence of necrotic margins and compared with clinical outcome of ORN persistence at follow-up.ResultsMedian follow-up was 17.4 months. Eight specimens had histologic evidence of necrotic, nonviable bone at the margins of resections; however, there was no progression of disease among patients in this group. Twenty-six specimens were clear of necrotic margins; however, 8 patients from this group developed persistent disease.ConclusionsIrradiated mandible is susceptible to ORN progression even if clinical and final histopathologic assessments confirm complete resection of necrotic bone margins. Progression of disease in ORN is not related to inadequate resection of necrotic bone.
Journal: American Journal of Otolaryngology - Volume 33, Issue 5, September–October 2012, Pages 576–580