Significance of adjunctive mitomycin C in endoscopic dacryocystorhinostomy

PurposeThe purpose of this study is to observe the effect of intraoperative topical application of mitomycin C (MMC) on the results of endoscopic dacryocystorhinostomy.DesignThis is a prospective, randomized, controlled, single-blind study.SettingsHospitalized treatment was done in a tertiary medical college hospital and research center that deals with a predominantly rural population.PatientsPatients with primary acquired postsaccal obstruction causing chronic dacryocystitis were considered.MethodsA total of 38 patients were randomized into either a mitomycin group or a control group. Both of these groups were subjected to an identical surgical procedure, except that 0.2 mg/dL of MMC was used in the mitomycin group, whereas normal saline was used in the control group. The follow-up period was at least 6 months. An asymptomatic patient with a visible stoma at nasendoscopy and free flow of saline into the nose with lacrimal syringing after 6 months after surgery was used as criteria for defining a successful result.ResultsThe success rate was 82.3% when MMC was used and 85.7% among the controls (P > .05). Granulations, adhesions, and obliterative sclerosis occurred in a similar number of patients of both groups. However, granulations and adhesions did not have a bearing on the success rate in either group.ConclusionMitomycin C did not appear to influence the occurrence of granulations, synechiae, or obliterative sclerosis, nor did it alter the success rate significantly.