کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
410969 | 679175 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of NMDA and non-NMDA receptors antagonists on the dynamic behavior of cultured cortical networks
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
هوش مصنوعی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Non-conventional electrophysiological techniques allow screening the activity of nerve cells in spontaneous and stimulus-evoked conditions. Activity patterns in cultured networks of cortical neurons from rat embryos were investigated at different days in vitro (DIV), by a multi-site recording technique based on planar microelectrode arrays (MEAs). Transitions in neuronal dynamics of the networks were induced by administering antagonists of NMDA and non-NMDA receptors. Neurochemical effects on synaptic transmission were evaluated analyzing the network activity by using ad hoc developed algorithms. A decrease in excitatory synaptic transmission corresponded to a decrease in spiking and bursting activity with a loss of synchronization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurocomputing - Volume 69, Issues 16–18, October 2006, Pages 1897–1903
Journal: Neurocomputing - Volume 69, Issues 16–18, October 2006, Pages 1897–1903
نویسندگان
L. Bonzano, M. Bove, S. Martinoia,