کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4109910 1605724 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and François Baclesse Cancer Care Center between 1998 and 2008
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Laryngeal preservation in ENT oncology. Retrospective series of 246 patients managed in the Caen University Hospital and François Baclesse Cancer Care Center between 1998 and 2008
چکیده انگلیسی

ObjectivesA 10-year retrospective study investigated factors for survival and laryngeal preservation in advanced laryngeal, hypopharyngeal or epilaryngeal neoplasia.Material and methodTwo hundred and forty-six patients with advanced cancer of the larynx (17.48%), hypopharynx (48.78%) or epilarynx (33.74%) undergoing primary organ-sparing treatment were included from 1998 to 2008. Treatment comprised chemotherapy followed by radiation therapy for 92.68% of patients, isolated radiation therapy for 1.6% and concomitant or sequential radiation-chemotherapy for 5.7%. General health status, history and tumor status were recorded. Factors influencing survival were analyzed by Kaplan-Meier estimator, log-rank test and Cox models.ResultsMedian overall survival of the population was 2.3 years and median laryngeal preservation 0.99 years in male patients and 2 years in female patients. Survival correlated significantly with body mass index (BMI; P = 0.0004), WHO performance status (P = 0.0064), alcohol consumption (P = 0.0004) and cessation (P < 0.0001) and also T stage (P = 0.0038), initial laryngeal mobility (P = 0.0002) and post-chemotherapy assessment (P < 0.0001). Survival with functional larynx correlated with baseline BMI at first consultation (P = 0.016), baseline WHO grade (P = 0.0005), laryngeal mobility (P < 0.0001), T staging (P = 0.0009), and T and/or N chemotherapy response to a classical organ preservation protocol (P < 0.0001).ConclusionOver and above established criteria, the present study highlighted the importance of general health and nutritional status during treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Annals of Otorhinolaryngology, Head and Neck Diseases - Volume 132, Issue 3, June 2015, Pages 129–134
نویسندگان
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