کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4112313 | 1606026 | 2012 | 6 صفحه PDF | دانلود رایگان |
ObjectiveWe have previously reported that surgical removal of the nasopharyngeal adenoid in young children resulted in increased risk of nasopharyngeal colonization by pneumococci. We now investigated whether adenoidectomy influences the development of serum IgG antibodies to pneumococcal choline-binding protein A (CbpA) and pneumococcal surface protein A (PspA).MethodsAltogether 217 children aged 12–48 months who had recurrent or persistent otitis media were randomized to undergo or not to undergo adenoidectomy. All the children underwent insertion of tympanostomy tubes. 166 children were followed-up for 3 years. The main outcome measures were concentrations of serum IgG antibodies to CbpA and PspA three years after randomization. Nasopharyngeal colonization by pneumococci was assessed 1, 2, and 3 years after randomization.ResultsAdenoidectomy decreased concentrations of CbpA antibodies by ca. 25% independently of the observed increase in pneumococcal carriage (OR of log10 transformed concentrations 0.74, 95% CI 0.58–0.94, P = 0.016). Concentrations of PspA antibodies were lower and they seemed not to be influenced by adenoidectomy.ConclusionsAdenoidectomy in young children causes a small but detectable impairment in the development of serum IgG antibodies to pneumococcal CbpA. The adenoid seems to have a role in augmenting systemic immunity against pneumococci.
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 76, Issue 11, November 2012, Pages 1569–1574