کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4112476 | 1606028 | 2012 | 4 صفحه PDF | دانلود رایگان |
BackgroundAllergic rhinitis is among the most common chronic disorders of childhood with prevalence of up to 40% in children. Clara cell secretory protein (CCSP) is secreted by Clara cells in the lining fluid of airways. It has an immune-modulatory and anti-inflammatory activity.Aim of workStudy aimed at evaluating CCSP as a biomarker in serum and nasal lavage fluid of children with allergic rhinitis.MethodsA case-control study was conducted on sera and nasal lavage fluid samples from 15 children with allergic rhinitis and 15 healthy children as a control group.ResultsChildren with allergic rhinitis had a male to female ratio 2 to 1, with a mean age of 9.47 ± 2.75 years, while among the healthy group, six were males and nine were females, with a mean age of 8.63 ± 2.28 years. Rhinorrhea and nasal obstruction were the most frequent symptoms (100%) followed by itching (93.3%) then sneezing (73.3%). Among allergic rhinitis patients serum CCSP mean ± SD was 2.03 ± 0.59 μg/l; it was reliable to predict allergic rhinitis (P < 0.0001); while nasal lavage CCSP mean ± SD was 12.73 ± 8.25 μg/l and it was not reliable to predict allergic rhinitis. Its best cut-off value was 3.75 μg/l with a sensitivity of 100%, specificity 80%, with a diagnostic accuracy of 90%.ConclusionClara cell secretory protein is a new peripheral sensitive marker of airway injury. Furthermore, serum CCSP level is a predictor of allergic rhinitis but not nasal lavage fluid CCSP.
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 76, Issue 9, September 2012, Pages 1241–1244