کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4112839 1606056 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repair
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
The use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repair
چکیده انگلیسی

ObjectiveTo evaluate the efficacy of topical mitomycin in providing the patency of the neochoanae in children undergoing transnasal endoscopic congenital choanal atresia (CA) repair.MethodsA retrospective analysis of surgical results in CA patients who were treated in Selcuk University, Meram Medical Faculty, Department of Otolaryngology between November 2002 and November 2009 was performed. All patients underwent transnasal endoscopic approach using nasal telescopes and traditional sinus instrumentation together with a microdebrider. Mitomycin was used according to the senior surgeon's preference, and certainly not in a randomized fashion. After completion of surgery, mitomycin 0.4 mg/ml was applied to the neochoanae for 3 min. Postoperative stenting was performed in all patients.ResultsCA was unilateral in 8 subjects (mean age 71.8 ± 41.7 months; range 18 months–144 months) and bilateral in 12 subjects (mean age 4.6 ± 1.3 days; range 3–7 days). Among the subjects, 75% was female in both groups. Fourteen subjects under endoscopic repair without mitomycin, whereas mitomycin was used in 6 patients (4 bilateral, 2 unilateral). Stents were left at least 3 weeks postoperatively (mean 31 ± 10 days; range 21–45 days). The patients were followed-up at least 6 months (range 6–72 months). No symptomatic restenosis requiring further dilatations was seen in patients treated with preoperative mitomycin, whereas restenosis was detected in 6 subjects (42.9%) treated without mitomycin postoperatively within 6 months period (Fisher's Exact Test 2-sided, p = 0.12). These subjects underwent revision endoscopic repair with mitomycin and had no need for further dilatations with acceptable control of symptoms during a follow-up period ranging between 14 and 78 months.ConclusionMitomycin improves the surgical treatment outcome of CA and reduces the rate of restenosis significantly without any complications. However, further prospective randomized studies are needed to fully investigate the benefits of mitomycin therapy in CA surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 74, Issue 7, July 2010, Pages 733–736
نویسندگان
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