کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4112962 1606033 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis
چکیده انگلیسی

ObjectivePhospholipase A2 (PLA2) plays a major part in growth regulation, differentiation and inflammation. It has been proposed as an evaluating marker for infection and inflammation. The aim of this study was to investigate activity of serum type II secretory PLA2 (sPLA2 IIa) in obstructive sleep apnea (OSA) and recurrent infective tonsillitis (RT) in children.MethodsActivity of serum sPLA2 IIa was determined in children who underwent tonsillectomy, including OSA in 126 cases and RT in 60. Serum enzyme activities were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholin as substrate.ResultsThe sPLA2 IIa activity of serum was significantly higher in RT than in OSA (P < 0.01). Serum sPLA2 IIa activity in the RT patients was positively correlated with BMI (r = 0.26; P = 0.02), which was not apparent in OSA (r = 0.14; P = 0.09).ConclusionThis study suggests that serum sPLA2 IIa activity may be considered as a supportive diagnostic marker in suspected or clinically unclear cases of RT children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 76, Issue 4, April 2012, Pages 471–474
نویسندگان
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