کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4113820 | 1606067 | 2009 | 5 صفحه PDF | دانلود رایگان |

ObjectiveThe role of allergy in the pathophysiology of otitis media with effusion (OME) remains unclear. We evaluated the role of allergy and the Th1/Th2 balance in OME patients.MethodMiddle ear fluid was collected from 46 OME patients who had a ventilating tube inserted, and expression of GATA3, T-bet, IL-4, and IFN-γ mRNA was assessed by RT-PCR. Expression of transcription factors and cytokines was compared in patients with and without allergy.ResultsThe levels of GATA3 and T-bet mRNA in effusion fluid correlated positively with the levels of IL-4 and IFN-γ mRNA, respectively. However, the allergy and non-allergy groups showed no significant differences in expression of any of these transcription factors and cytokines. The T-bet:GATA3 ratio was higher in the non-allergy than in the allergy group, but the difference was not statistically significant.ConclusionAlthough we observed a significant positive correlation between GATA3 and IL-4 mRNA levels, we cannot conclude that OME with allergy is related to a Th-2 driven immune response.
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 73, Issue 8, August 2009, Pages 1119–1123