کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4113922 1606054 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extending the chinchilla middle ear epithelial model for mucin gene investigation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Extending the chinchilla middle ear epithelial model for mucin gene investigation
چکیده انگلیسی

ObjectivesTo investigate the expression of recently identified human mucin genes in an in vivo model of the chinchilla middle ear epithelium (CMEE).MethodsCMEE was harvested, RNA was extracted and primers were designed for RT-PCR to assess for expression of mucin genes Muc6, Muc17 and Muc18. Further sequencing of these genes was also accomplished.ResultsMucin genes Muc6, Muc17 and Muc18 was assessed and found to be identical to the expression in human and mouse MEE.ConclusionThis study further characterizes mucin gene expression in the CMEE and provides additional sequence data for chinchilla middle ear genes. The concordance of this gene expression data to that of both the human and mouse models further demonstrates the utility of this animal model in OM investigations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 74, Issue 9, September 2010, Pages 980–985
نویسندگان
, , ,