کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4114067 1606057 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of oseltamivir treatment on the incidence and course of acute otitis media in children with influenza
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Impact of oseltamivir treatment on the incidence and course of acute otitis media in children with influenza
چکیده انگلیسی

ObjectiveAcute otitis media (AOM) is the most common complication of pediatric influenza, and imposes a substantial health care burden. We examined the influence of oseltamivir treatment on the incidence and course of AOM in children with influenza.MethodsIn the original study, 695 children 1–12 years who presented within 48 h of the onset of influenza-like symptoms were randomized to oseltamivir (2 mg/kg) or placebo given twice daily for 5 days. AOM was assessed at enrollment and days 3, 6 (±1), 10 (±2) and 28 (±7). AOM was clinically diagnosed by the participating primary care provider, supported by tympanometry when possible. We performed a retrospective analysis of those participants with laboratory-confirmed influenza (LCI). Assessments included the incidence and clinical course of new AOM cases.ResultsIn all, 452 children had LCI; 217 received oseltamivir and 235 placebo. AOM was diagnosed on or after study day 3 at a significantly lower frequency in the oseltamivir versus placebo group (12.4% versus 21.7%; relative risk [RR]: 0.57 [95% CI: 0.37, 0.88], respectively). Treatment effects were greatest for children 1–2 years (RR = 0.42 [95% CI: 0.20, 0.89]) and 3–5 years (RR = 0.45 [95% CI: 0.19, 1.04]), in whom the incidence of AOM was highest.ConclusionsOseltamivir treatment significantly reduces the emergence of new AOM infections in children with LCI; effects are most pronounced in those <5 years. Clinical trial number: WV15758.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 74, Issue 6, June 2010, Pages 684–688
نویسندگان
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