کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4129651 | 1606470 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lobular neoplasia diagnosed on breast Core biopsy: frequency of carcinoma on excision and implications for management
ترجمه فارسی عنوان
نئوپلاسم لوبولای بر روی بیوپسی هسته ای تشخیص داده می شود: فراوانی کارسینوم در برداشت و پیامدهای آن برای مدیریت
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کلمات کلیدی
پستان، غربالگری، تشخیص، بیوپسی هسته، هیپرپلازی لوبالری آتیپیک، کارسینوم لوبولار در محل، نئوپلازی لوبولار،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
چکیده انگلیسی
The appropriate follow-up and treatment for patients with a core biopsy diagnosis of lobular neoplasia (atypical lobular hyperplasia or lobular carcinoma in situ) remains controversial. Several studies have attempted to address this issue, with recommendations ranging from close clinical follow-up or surveillance to mandatory surgical excision in all cases. We report the findings at our institution, where virtually every core needle biopsy diagnosis of lobular neoplasia results in follow-up excision. The goal of the study was to identify potential predictors of upgrade to a more significant lesion. We identified 76 patients over a 15-year period with a core biopsy diagnosis of pure lobular neoplasia and no other high-risk lesions. Subsequent surgical excision identified 10 cases (13%) that were upgraded to carcinoma. Upgrade diagnoses included invasive ductal carcinoma (n = 1), invasive lobular carcinoma (n = 4), ductal carcinoma in situ (n = 3), and pleomorphic lobular carcinoma in situ (n = 2). All 10 upgraded cases had imaging findings suspicious for malignancy including irregular masses, asymmetric densities, or pleomorphic calcifications. Of the 10 upgraded cases, 7 were diagnosed as lobular carcinoma in situ on core biopsy. The data support a role for radiologic-pathologic correlation in the evaluation of suspicious breast lesions and suggest that the extent of lobular neoplasia in core biopsy specimens may be an indicator of the likelihood of upgrade to carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Diagnostic Pathology - Volume 25, December 2016, Pages 20-25
Journal: Annals of Diagnostic Pathology - Volume 25, December 2016, Pages 20-25
نویسندگان
Benjamin C. MD, PhD, Angela M.B. MD, PhD, Abberly A. MD, Esther N. MD, Leah R. MD, Christine N. MD, Erinn DO,