کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4132524 1606662 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Remote infarct of the temporal lobe with coexistent hippocampal sclerosis in mesial temporal lobe epilepsy
ترجمه فارسی عنوان
انفارکتوس از راه دور لوب تمپورال با اسکلروز هیپوکامپ همجنسگرایان در صرع لوب مریولی مسیال
کلمات کلیدی
اسکلروز هیپوکمپ، انفارکتو از راه دور، صرع، دیسپلازی قشر مرکزی، پاتولوژی دوگانه
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی

SummaryIn patients undergoing surgery for temporal lobe epilepsy, hippocampal sclerosis remains the most commonly observed pathology. In addition to hippocampal sclerosis, 5% to 30% of these resections on magnetic resonance imaging contain a second independently epileptogenic lesion, commonly referred to as dual pathology. A second etiology of seizure activity, as seen in dual pathology, may serve as an important cause of treatment failure in striving for post-operative seizure control. Dual pathology, consisting of hippocampal sclerosis and a remote infarct of the adjacent cortex, has been rarely reported. Cases of pathologically confirmed hippocampal sclerosis diagnosed between January 2000 and December 2012 (n = 349) were reviewed, and 7 cases of coexistent infarct (2%) formed the study group. Seven individuals (mean age, 29 years; range, 5-47 years) with a mean epilepsy duration of 12.5 years (3.3-25 years) and a mean pre-surgery frequency of 15 seizures per week (range, 0.5-56 seizures/week) were followed up postoperatively for a mean duration of 64 months (range, 3-137 months). Pathologically, the most common form of hippocampal sclerosis observed was International League against Epilepsy type Ib or severe variant (n = 4). Four of the six individuals with post-surgery follow-up were seizure free at last encounter. The reported incidence of dual pathology, including hippocampal sclerosis and remote infarct, is low (2% in the present study) but may indicate a slightly increased risk of developing hippocampal sclerosis in the setting of a remote infarct. Surgical intervention for such cases anecdotally appears effective in achieving seizure control.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 48, February 2016, Pages 111–116
نویسندگان
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