کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4132721 1271393 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma
چکیده انگلیسی

SummarySmall cell carcinoma (SmCC) of the prostate is a rare and aggressive histologic subtype of the prostate cancer. It can sometimes mimic acinar adenocarcinoma with a high Gleason score (GS). A previous study showed that immunohistochemical staining for CD44 could help in the differential diagnosis of these 2 entities. In this study, we used 2 tissue microarrays including 63 cases of prostate cancer (18 pure SmCC, 37 pure acinar adenocarcinoma, and 8 mixed acinar adenocarcinoma and SmCC) to validate the value of CD44. When analyzed as a continuous variable, CD44 positivity was significantly higher in acinar adenocarcinoma with GS 8 than GS 9 to 10 (P = .027). However, the difference of CD44 expression between SmCC and acinar adenocarcinoma was insignificant. The current study fails to confirm the value of CD44 in differential diagnosis between prostatic SmCC and acinar adenocarcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 46, Issue 4, April 2015, Pages 554–557
نویسندگان
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