کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4132773 | 1271394 | 2013 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Epstein-Barr virus–positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection–associated T/NK-cell lymphoproliferative disorder: a case report Epstein-Barr virus–positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection–associated T/NK-cell lymphoproliferative disorder: a case report](/preview/png/4132773.png)
SummaryA 30-year-old female patient presented with intestinal Epstein-Barr virus (EBV)–positive cytotoxic T-cell lymphoma (EBV+ CTL), which was surgically resected. Fourteen years later, she returned to our hospital with hypersensitivity to mosquito bites and was diagnosed with chronic active EBV infection–associated T/NK-cell lymphoproliferative disorder (CAEBV/TNK-LPD). She developed systemic EBV+ CTL at age 47 years during the 2.5-year clinical course of CAEBV/TNK-LPD, despite multiagent chemotherapy and allogeneic stem cell transplantation. Afterward, she had a rapidly deteriorating clinical course and died at age 48 years. The immunophenotype of the EBV+ CTL was consistently a CD3, CD8, and cytotoxic molecule-positive type with the same clonality in polymerase chain reaction analysis of T-cell receptor-γ chain gene rearrangement. This is the first reported case of EBV+ CTL preceding the clinical presentation of CAEBV/TNK-LPD. The present case was unique in suggesting a close relationship between EBV+ CTL and chronic active EBV infection.
Journal: Human Pathology - Volume 44, Issue 12, December 2013, Pages 2849–2852