کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4134216 | 1271450 | 2010 | 6 صفحه PDF | دانلود رایگان |

SummaryRecent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors—Sox9, Runx2, and Osterix—were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors—chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma—using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.
Journal: Human Pathology - Volume 41, Issue 12, December 2010, Pages 1788–1793