کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4134216 1271450 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors
چکیده انگلیسی

SummaryRecent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors—Sox9, Runx2, and Osterix—were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors—chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma—using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 41, Issue 12, December 2010, Pages 1788–1793
نویسندگان
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