کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4134403 1271458 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features
چکیده انگلیسی

SummaryThe 2004 World Health Organization classification system for urothelial neoplasia classifies flat-related preneoplastic lesions as urothelial hyperplasia (flat and papillary), reactive urothelial atypia, urothelial atypia of unknown significance, urothelial dysplasia (low-grade intraurothelial neoplasia), and urothelial carcinoma in situ (high-grade intraurothelial neoplasia). Each lesion is defined with precise nomenclature and strict morphologic criteria. In many cases, morphologic features alone suffice for diagnosis. Other cases may require a panel of immunohistochemical antibodies consisting of cytokeratin 20, p53, and CD44 for diagnosis. Recent molecular studies have provided further insight into the premalignant potential of these urothelial lesions. Herein, we present a review of flat urothelial lesions of the urinary bladder as defined by the 2004 World Health Organization classification with focus on the clinicopathologic, immunohistochemical, and molecular features.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 41, Issue 2, February 2010, Pages 155–162
نویسندگان
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