کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4135305 1271490 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Invasive carcinoma arising from a colonic adenoma with clear cell change
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Invasive carcinoma arising from a colonic adenoma with clear cell change
چکیده انگلیسی

SummaryClear cell change (CCC) in colonic adenoma is rare, and its biological and clinical significance remains unknown. Malignant progression of an adenoma with CCC has seldom been reported. We report a case of a sigmoid adenoma with multiple foci of CCC associated with high-grade dysplasia and invasive carcinoma in a 62-year-old patient. We evaluated the histochemical and immunohistochemical characteristics of each component of the adenoma. In contrast to other parts of the adenoma, p53 was strongly and diffusely overexpressed in the areas of CCC, high-grade dysplasia, and carcinoma. The MIB-1 labeling index was also significantly higher in these components than in other parts of the adenoma. In conclusion, our findings suggest that CCC in adenoma may be associated with malignant progression of the adenoma. Hence, for practical purposes, we recommend considering CCC in colonic adenomas as a high-grade dysplasia equivalent and following up the patient accordingly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 39, Issue 9, September 2008, Pages 1402–1405
نویسندگان
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