کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4135330 | 1271491 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease](/preview/png/4135330.png)
SummaryImmunoglobulin (Ig) G4–related systemic disease is a recently characterized entity. The best-known manifestation is pancreatitis. Other systemic involvements are also described. Three cases of this disease with hypophyseal involvement have been reported in the literature, all diagnosed clinically. We herein present the first case of IgG4-related hypophysitis diagnosed histopathologically. The patient is a 77-year-old Chinese man with a pituitary tumor. Histologic examination of the resected tumor showed hypophysitis with features of inflammatory pseudotumor. Clinical review showed history of pancreatitis and cholecystitis 4 years ago. The pancreatic biopsy and gall bladder specimens obtained previously had the same pathologic features of inflammatory pseudotumor. Immunohistochemistry highlighted abundant IgG4-positive plasma cells in all 3 specimens. Serum IgG4 level was also elevated. A diagnosis of IgG4-related systemic disease was confirmed. This is the first case of intracranial inflammatory pseudotumor shown to be associated with IgG4-related systemic disease.
Journal: Human Pathology - Volume 38, Issue 11, November 2007, Pages 1720–1723