کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4135346 | 1271492 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Expression of p53 in virally infected tubular cells in renal transplant patients with polyomavirus nephropathy Expression of p53 in virally infected tubular cells in renal transplant patients with polyomavirus nephropathy](/preview/png/4135346.png)
SummaryPolyomavirus (PV) infection is associated with ureteral stenosis, hemorrhagic cystitis, and interstitial nephritis in renal transplant patients. The 3 PVs detected in human beings—BK virus, JC virus, and simian virus 40—each encode highly homologous forms of a large T antigen, a transcriptional and replicational regulatory protein. We describe immunohistochemical findings in 5 renal transplant patients who developed PV nephropathy (PVN) and a sixth patient with both PVN and PV infection of the bladder mucosa. Polyomavirus infection was confirmed by immunohistochemical detection of T antigen in kidney and bladder biopsies. We report on the expression of p53 specific to virally infected cells in all biopsies positive for T antigen. Examination of posttransplant biopsies obtained from these 6 patients before they were diagnosed with PVN revealed no expression of T antigen or p53. Accumulation of p53 in PV-infected cells may occur in response to binding of p53 by T antigen, resulting in stabilization of p53. These results provide the first evidence for intracellular actions of PV T antigen in the context of nonneoplastic diseases.
Journal: Human Pathology - Volume 37, Issue 6, June 2006, Pages 684–688