کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4154817 1273728 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relapsed hepatoblastoma confined to the lung is effectively treated with pulmonary metastasectomy
ترجمه فارسی عنوان
هپاتوبلاستوما تجربی محدود به ریه به طور موثر با متاستازکتومی ریوی درمان می شود
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

BackgroundIn children diagnosed with hepatoblastoma (HB), the lungs are the most common site of metastasis at both initial presentation and relapse. Previous studies have encouraged pulmonary metastasectomy to achieve a disease-free state after resection of the primary hepatic lesion. However, there is no consensus about how to manage recurrent pulmonary metastasis.ProcedureA retrospective, multi-institutional review was performed from 2005 to 2014 to identify HB patients ≤ 18 years of age who had disease recurrence associated with pulmonary metastases alone.ResultsTen patients between the ages of 8 and 33 months were identified. Pulmonary metastatic recurrence was detected by measuring alpha-fetoprotein (AFP) levels and/or with CT scans of the chest. All patients subsequently underwent pulmonary metastasectomy without post-operative complications. At last follow-up, 8 patients were alive and had normal AFP levels. The 8 survivors had a median follow-up from therapy completion of 18.5 months. Two patients who presented with extrapulmonary recurrence subsequently died of treatment refractory disease.ConclusionsThis review supports surgical resection as a safe and, in the context of multimodal therapy, efficacious approach to manage HB patients who present with isolated pulmonary relapse.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 51, Issue 4, April 2016, Pages 525–529
نویسندگان
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