کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4155002 | 1273734 | 2015 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Heterotaxy syndrome and intestinal rotational anomalies: Impact of the Ladd procedure Heterotaxy syndrome and intestinal rotational anomalies: Impact of the Ladd procedure](/preview/png/4155002.png)
BackgroundChildren with heterotaxy syndrome and intestinal rotational anomalies (IRA) are at risk for midgut volvulus and ischemia. Controversy exists regarding risks and benefits of prophylactic Ladd procedures. The purpose of this study is to assess the impact of Ladd procedures on adverse events for children with heterotaxy and IRA.MethodsA retrospective cohort study using the Pediatric Health Information System (PHIS) database was performed. All children with heterotaxy and IRA admitted at age ≤ 30 days and discharged between 1/1/2004 and 1/1/2011 were included with a minimum 2-year follow-up period. The primary outcome was major morbidity, defined as a composite variable for intestinal obstruction/volvulus, ischemia, or resection, or inhospital mortality. Univariable and multivariable analyses were performed.ResultsThere were 325 patients who met the inclusion criteria, including 92 (28%) patients with single ventricles. Mean gestational age was 38.0 ± 2.1 weeks and birth weight was 3.1 ± 0.6 kg. Ladd procedure was performed during initial hospitalization on 188 (58%) children. In multivariable analyses, Ladd procedure on initial hospitalization was associated with a 2.2 times increased odds of adverse events on subsequent admissions (95% CI 1.3–4.0, p = 0.007).ConclusionsLadd procedure is associated with increased odds of adverse events for children with heterotaxy and IRA.
Journal: Journal of Pediatric Surgery - Volume 50, Issue 10, October 2015, Pages 1695–1700