کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4155525 1273749 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Management and outcome of neuroendocrine tumours of the appendix—a two centre UK experience
ترجمه فارسی عنوان
مدیریت و نتیجه تومورهای عصبی عضلانی آپاندیس یک تجربه دو مرکز انگلستان است
کلمات کلیدی
ضمیمه، تومور کارسینوئی (ها)، تومورهای عصبی عصبی (ها)، جراحی رادیکال، آپاندیکتومی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی

BackgroundNeuroendocrine tumours (NET) of the appendix are rare histopathological neoplasms detected following operation for appendicitis in childhood. The role (if any) for radical surgery notably right hemicolectomy (RHC) has often reflected the ‘expert opinion’ of adult general surgeons with wider experience of managing NET lesions of the gastrointestinal tract. Critical decisions have focused on (a) tumour size, (b) histology, (c) tumour location/invasion and (d) positive lymph nodes. Against this background we report the clinical outcome of children with ‘incidental’ appendix carcinoid tumours managed at two regional UK paediatric surgery centres. A critical review of the literature is additionally provided in an effort to define contemporary patterns of care in paediatric surgical practice.MethodsHospital records and pathology database(s) identified 27 patients at two UK centres with a confirmed histological diagnosis of appendix NET lesions during January 1997–January 2013. A PUBMED and EMBASE search strategy—(English language publications only), 1975–present, was performed to gather information on all patients younger than 20 years at primary diagnosis with NET appendix tumours to review their management and outcomes.ResultsAll 27 patients treated at the two institutions had acute appendicitis including 3 cases presenting with an appendix mass. Twenty-five underwent appendicectomy with two having interval operations. Tumours had a maximum diameter of 2–18 mm (median 9 mm) with 73% of lesions located at the appendix tip. Fourteen (52%) had tumour invading the mesoappendix. All patients underwent appendicectomy only with no single case having RHC or additional surgery. Surveillance studies (5HIAA, chromogranin-A) and imaging including ultrasound or CT were deployed in a minority of patients revealing no abnormality. All 27 cases are alive and well—(mean follow up 5 years; range: 9 months–16 years). The literature highlights varied management strategies and no recorded fatalities with radical surgery in children largely evolving from adult surgical practice.ConclusionsThis study confirms that paediatric patients with ‘incidental’ NET tumours of the appendix have an excellent prognosis. Consensus guidelines should ideally be developed by paediatric oncology surgeons to avoid unnecessary radical surgery in many otherwise healthy children.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 49, Issue 10, October 2014, Pages 1513–1517
نویسندگان
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