کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4156171 1273769 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Congenital diaphragmatic hernia (CDH) mortality without surgical repair? A plea to clarify surgical ineligibility
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Congenital diaphragmatic hernia (CDH) mortality without surgical repair? A plea to clarify surgical ineligibility
چکیده انگلیسی

PurposeLittle is known about liveborn CDH patients who die without surgery. We audited a national CDH cohort to determine whether these patients were different from patients who received CDH repair.MethodsA national CDH database was analyzed (2005–2009). After excluding infants with severe physiologic instability and genetic/congenital malformations, a potential surgical candidate (PSC) subgroup was identified. PSCs were compared to the operative group (OG) and the operative non-survivor (ONS) subgroup. Standard statistical analyses were performed.ResultsOf 275 liveborns, 35 (13%) died without surgery. The PSC subgroup (n = 11) had a median survival of 10 days (range: 3–18). Ten of 11 PSC infants were treated in ECMO centers, with 4 receiving ECMO. No differences in BW, GA, and rates of minor malformation were observed between PSC and OG patients. While neonatal illness severity (SNAP-II) predicted overall mortality, SNAP-II scores were similar between PSC and ONS groups (34 vs. 29; p = 0.431). Furthermore, greater than 80% of infants with SNAP-II scores between 30 and 39 survived in the OG cohort.ConclusionOur analysis demonstrated that PSCs were similar to infants offered surgery based on illness severity and the presence of congenital malformations. We suggest that criteria for surgical ineligibility be developed to standardize the selection of surgical candidates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 48, Issue 5, May 2013, Pages 924–929
نویسندگان
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