کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4156330 1273771 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Lung to head ratio in infants with congenital diaphragmatic hernia does not predict long term pulmonary hypertension
چکیده انگلیسی

PurposeLung-to-head ratio (LHR) has been used for antenatal evaluation of infants with congenital diaphragmatic hernia (CDH). We hypothesized that LHR was predictive of acute and chronic pulmonary hypertension in infants with CDH.MethodsEchocardiograms on all inborn infants with CDH (December 2001–March 2011) were reviewed. Echocardiograms at 1 and 3 months post-repair and most recent follow-up were assessed for presence of pulmonary hypertension (PAH). LHR, gestational age, birth weight, extracorporeal membrane oxygenation (ECMO), and death rate were obtained. Bivariate and multivariate analyses were performed.Results106 infants with CDH had LHR obtained at median 28 weeks gestation (median LHR = 1.25 [range 0.4–5.3]). Median follow-up was 26.6 months (range 4.6–97.5). The long-term incidence of pulmonary hypertension was 16%. LHR was significantly associated with pulmonary hypertension at one month (p = 0.0001) but not at 3 months (p = 0.22) or long-term (p = 0.54). LHR was predictive of ECMO use (p = 0.01) and death (p = 0.001).ConclusionsThe overall incidence of PAH in infants with CDH decreases over time. Prenatal LHR predicts PAH at one month but not long-term in infants with CDH. The ability for LHR to predict PAH at one month but not long term may suggest remodeling of the pulmonary vasculature over time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 48, Issue 1, January 2013, Pages 154–157
نویسندگان
, , , , , , , ,