کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4156366 1273771 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Medullary thyroid carcinoma in ethnic Chinese with MEN2A: A case report and literature review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Medullary thyroid carcinoma in ethnic Chinese with MEN2A: A case report and literature review
چکیده انگلیسی

Medullary Thyroid Carcinoma (MTC) is the most common cause of death in MEN patients.It is curative by prophylactic total thyroidectomy, but controversies remain as to the optimal timing for prophylactic thyroidectomy. The current recommendation is for prophylactic total thyroidectomy before age 5, but a recent study suggested that in the ethnic Chinese, even “high risk” mutations did not result in early malignant change, and it was suggested that prophylactic thyroidectomy may be performed at a later age. We report a case of an ethnic Chinese girl with MEN2A codon 634 (C634R) mutation, whose operative specimen at prophylactic thyroidectomy at 4 years 8 months showed MTC. We advocate that management of MEN2A patients should be codon-directed, regardless of ethnicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 48, Issue 1, January 2013, Pages e43–e46
نویسندگان
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