Urinomas protect renal function in posterior urethral valves—a population based study

Background/PurposeUrinomas have been thought to protect renal function in boys with posterior urethral valves (PUVs), although recent reports have disputed this. This study tested the hypothesis that urinomas protect global renal function in boys with PUV.MethodsA retrospective analysis of all boys with PUV presenting to a tertiary unit derived from a region with an estimated population of 5.5 million was performed. Comparisons of the initial nadir creatinine, current creatinine, and renal status score (RSS) were made between those with and without urinomas. The RSS was derived from nephrology assessment of current renal status (0 = normal to 4 = end-stage renal failure or transplantation). Results were given as median (range), except for RSS, which was given as mean ± SEM. P ≤ .05 was regarded as significant.ResultsDuring 1989-2009, 9 of 89 PUV boys were diagnosed with urinomas. Initial nadir creatinine was statistically lower in boys with urinomas (31 [18-44] vs 45 [20-574] μmol/L, P < .01). Length of follow-up was similar (5.1 [2.2-17.3] vs 5.9 [1.8-19.7] years, P = .59). Follow-up creatinine was significantly lower in urinoma boys (44 [25-77] vs 61 [29-1227] μmol/L, P < .05), as was the RSS (0.14 ± 0.14 vs 0.91 ± 0.14, P < .01). No urinoma boys progressed to end-stage renal failure or required transplant.ConclusionThis population-based study of PUV boys demonstrates that urinomas reduce nadir creatinine and significantly protect long-term global renal function.