کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4158884 1273818 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of augmentation cystoplasty on bladder contractility in rabbits
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Effects of augmentation cystoplasty on bladder contractility in rabbits
چکیده انگلیسی

Background/PurposeAn experimental study was conducted to investigate the effects of colocystoplasty and prefabricated cystoplasty on the bladder contractility in rabbits.MethodsTwenty-eight female New Zealand rabbits were randomly allocated into sham-operated controls, sigmoid enterocystoplasty (SECP), and prefabricated enterocystoplasty (PECP) groups. Augmentation cystoplasty with a 2-cm colon segment was performed in the SECP group. Mucosa was removed from the isolated sigmoid colon and covered with uroepithelial grafts from the bladder mucosa in the PECP group. Two weeks after the replacement of mucosa, enterocystoplasty was performed. Isometric contractions obtained by electrical field stimulation (EFS) and acetylcholine were evaluated in the bladder strips, 3 weeks after the operations.ResultsBladder strips obtained from the experimental groups displayed similar basal rhythmic activity. Electric field stimulation elicited a frequency-dependent contractile activity, which was lower between 1 to 20 Hz stimulation in the SECP- and PECP-operated animals. Acetylcholine elicited concentration-dependent contractions in all groups. Acetylcholine-induced contractile responses were greater in the PECP group.ConclusionsThis study demonstrated that an augmented bladder prepared either with a sigmoid colon or prefabricated seromuscular flap displayed contractile activity similar to normal bladder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 43, Issue 7, July 2008, Pages 1347–1352
نویسندگان
, , , , ,