کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4160430 1273843 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carbon dioxide pneumoperitoneum prevents intraperitoneal adhesions after laparotomy in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Carbon dioxide pneumoperitoneum prevents intraperitoneal adhesions after laparotomy in rats
چکیده انگلیسی

PurposeThe aim of this study was to assess whether carbon dioxide insufflation (CDI) pneumoperitoneum prevents intraperitoneal adhesions (IPAs).MethodsLaparotomy was performed in 40 8-week-old Lewis rats and their bowels delivered through the wound and manipulated. The rats were divided into 4 groups, namely, those that would have laparotomy (Lp group, n = 15), Lp with CDI (Lp-CDI group, n = 15), Lp and bowel anastomosis (LpBA group, n = 5), and LpBA with CDI (LpBA-CDI group, n = 5). LpBA and LpBA-CDI group rats had 1 cm of ileum excised and end-to-end anastomosis performed. To accelerate IPA formation, all rats then had their bowels heated to 45°C for 40 seconds and 0.5 mL of Lewis rat blood spilled over them. Rats in the control group (n = 5) had Lp alone without heating or blood spillage. Pneumoperitoneum involved insufflating carbon dioxide into the peritoneal cavity through a cannula at the time of final abdominal closure to create pneumoperitoneum to a pressure of 5 mm Hg. All rats had relaparotomy 10 days after surgery and IPAs were assessed blindly using an IPA severity score (IPASS: 0 = no adhesions, 1 = no serosal tears during adhesiolysis, 2 = serosal tears during adhesiolysis, 3 = bowel perforation during adhesiolysis). Only the worst IPA in each rat was scored. Rats were killed after the peritoneum and bowels were excised for histopathology.ResultsPneumoperitoneum resolved in approximately 5 days. There were no associated side effects. The Lp-CDI group had significantly lower IPASS than the Lp group (0.23 ± 0.46 vs 1.07 ± 1.18, P < .05), and the LpBA-CDI group had significantly lower IPASS than the LpBA group (1.50 ± 0.61 vs 2.40 ± 0.55, P < .05). Histopathology showed pneumoperitoneum had no effect on the peritoneum or bowels.ConclusionsOur results suggest that CDI pneumoperitoneum appears to prevent IPA, especially between bowel-bowel IPA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pediatric Surgery - Volume 41, Issue 5, May 2006, Pages 1025–1028
نویسندگان
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