کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4165512 | 1607475 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Colchicine is a Safe Drug in Children with Familial Mediterranean Fever Colchicine is a Safe Drug in Children with Familial Mediterranean Fever](/preview/png/4165512.png)
ObjectiveTo identify any adverse effects of colchicine in a pediatric patients with familial Mediterranean fever (FMF).Study designClinical presentation, Mediterranean fever gene genotype, disease duration, colchicine dose, laboratory tests, and reported adverse effects in children with FMF were analyzed.ResultsOf the 153 patients with FMF, 22 (14.4%) developed diarrhea during a follow-up of 4 years; the colchicine dose was reduced to control this symptom in only 4 patients. In 18 (11.8%) patients, a mild transitory increase of transaminases (45-158 IU/L) was found during a follow-up of 1 year. Blood cell counts and kidney function tests were normal in all patients. No correlation was found between the adverse effects and patient's age, disease onset, treatment duration, or any of the clinical characteristics of the disease.ConclusionColchicine is a safe drug in the treatment of children with FMF, even in infancy. The only significant adverse effects are diarrhea (in a small number of patients), which can be controlled by a decrease in the colchicine dose and transitory elevation of transaminases.
Journal: The Journal of Pediatrics - Volume 161, Issue 6, December 2012, Pages 1142–1146