کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4165822 | 1607489 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Gestational Alloimmune Liver Disease in Cases of Fetal Death Gestational Alloimmune Liver Disease in Cases of Fetal Death](/preview/png/4165822.png)
ObjectiveTo determine whether alloimmune liver disease can be identified as a cause of fetal death.Study designThis is a retrospective examination of the autopsy tissue of 6 stillborn fetuses and 2 extreme preterm infants (gestational age, 20 to 34 weeks) drawn from families referred for suspected neonatal hemochromatosis. Thirteen appropriate nondisease controls and 8 cases of neonatal acute liver failure with known etiology were also examined. Liver sections were immunostained using anti-human C5b-9 complex.ResultsAll of the study cases had died with no preceding evidence of fetal distress. Histopathology showed findings of acute liver injury, including global hepatocyte necrosis with minimal reticulum collapse and no fibrosis. Hepatocytes in cases stained strongly positively for C5b-9 complex, suggesting premortem lgG complement–mediated liver injury. Hepatocytes in acute liver failure case controls did not demonstrate a similar mechanism of liver injury.ConclusionsAlloimmune liver disease is sometimes associated with fetal death.
Journal: The Journal of Pediatrics - Volume 159, Issue 4, October 2011, Pages 612–616