کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4165822 1607489 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gestational Alloimmune Liver Disease in Cases of Fetal Death
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Gestational Alloimmune Liver Disease in Cases of Fetal Death
چکیده انگلیسی

ObjectiveTo determine whether alloimmune liver disease can be identified as a cause of fetal death.Study designThis is a retrospective examination of the autopsy tissue of 6 stillborn fetuses and 2 extreme preterm infants (gestational age, 20 to 34 weeks) drawn from families referred for suspected neonatal hemochromatosis. Thirteen appropriate nondisease controls and 8 cases of neonatal acute liver failure with known etiology were also examined. Liver sections were immunostained using anti-human C5b-9 complex.ResultsAll of the study cases had died with no preceding evidence of fetal distress. Histopathology showed findings of acute liver injury, including global hepatocyte necrosis with minimal reticulum collapse and no fibrosis. Hepatocytes in cases stained strongly positively for C5b-9 complex, suggesting premortem lgG complement–mediated liver injury. Hepatocytes in acute liver failure case controls did not demonstrate a similar mechanism of liver injury.ConclusionsAlloimmune liver disease is sometimes associated with fetal death.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 159, Issue 4, October 2011, Pages 612–616
نویسندگان
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