کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4166073 1607486 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lower Airway Nitric Oxide is Increased in Children with Sickle Cell Disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Lower Airway Nitric Oxide is Increased in Children with Sickle Cell Disease
چکیده انگلیسی

ObjectivesTo determine alveolar and airways nitric oxide (NO) levels in children with sickle cell disease (SCD).Study designMultiple flows fractional exhaled NO (FENO), bronchial NO flux (J’awNO), and alveolar NO concentration (CaNO) were determined prospectively in 16 non-atopic children with SCD in a tertiary ambulatory clinic and compared with those in 10 children with primary ciliary dyskinesia and 22 healthy control subjects. Differences in FENO, J’awNO, and CaNO were compared with mixed model analysis and Mann-Whitney tests.ResultsChildren with SCD had reference range FENO at 50 mL/sec, but FENO was elevated across all flows compared with healthy control subjects (mean difference = 2.10 ± 0.91 parts per billion, P = .03). Subjects with SCD had increased J’awNO (1177 ± 533 picoliters per second versus 833 ± 343 picolitres per second, P = .03), and CaNO was no different from control subjects. In contrast, children with primary ciliary dyskinesia had decreased FENO (mean difference = 3.36 ± 1.24 parts per billion, P < .01) and J’awNO (507 ± 259 picoliters per second versus 833 ± 343 picoliters per second, P < .01).ConclusionsLower airways NO is increased in children with SCD. Elevation of J’awNO may represent dysregulation of NO metabolism or subclinical airways inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 160, Issue 1, January 2012, Pages 93–97
نویسندگان
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