Intrauterine Inflammation as a Risk Factor for Persistent Ductus Arteriosus Patency after Cyclooxygenase Inhibition in Extremely Low Birth Weight Infants

Respiratory distress syndrome and intrauterine inflammation were independent risk factors for persistent ductus arteriosus after indomethacin therapy in extremely low-birth weight infants. Intrauterine inflammation may have a negative influence on ductus arteriosus closure via increased cyclooxygenase-1 activity.