کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4166623 1607531 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metabolic Responses to Early and High Protein Supplementation in a Randomized Trial Evaluating the Prevention of Hyperkalemia in Extremely Low Birth Weight Infants
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Metabolic Responses to Early and High Protein Supplementation in a Randomized Trial Evaluating the Prevention of Hyperkalemia in Extremely Low Birth Weight Infants
چکیده انگلیسی

ObjectiveTo determine whether early and higher intravenous amino acid (EHAA) supplementation decreases hyperkalemia in extremely low birth weight (ELBW) infants (<1000 g).Study designInfants were enrolled at birth in a randomized, double-masked, prospective fashion and treated for 7 days. The standard group (SAA) infants received intravenous amino acid (AA) starting at 0.5 g · kg−1 · d−1 and increased by 0.5 g · kg−1 every day to a maximum of 3 g · kg−1 · d−1. EHAA group infants received 2 g · kg−1 · d−1 of AA soon after birth and advanced by 1 g · kg−1 every day to 4 g · kg−1 · d−1. Data analysis was by SPSS 11.5, with statistical significance at α = 0.05 and 90% power to determine a difference in mean K+ level of 2.ResultsSixty-two patients, mean gestational age of 26.0 ± 2.0 weeks and birth weight of 775 ± 136 g, were enrolled. Hyperkalemia (K+ ≥6.5 mEq/L) occurred in 13% of the studied population; no difference in incidence of hyperkalemia was found between the SAA and EHAA groups (16% vs 10%, respectively, P = .70). Serum blood urea nitrogen was higher in the EHAA group. AA infusion was stopped early in 6 patients for high blood urea nitrogen or elevated ammonia level.ConclusionsDuring the study period, hyperkalemia decreased significantly and was not affected by EHAA supplementation in the first week of life.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 153, Issue 4, October 2008, Pages 535–540
نویسندگان
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