کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4166923 1607522 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ezetimibe Treatment of Pediatric Patients with Hypercholesterolemia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Ezetimibe Treatment of Pediatric Patients with Hypercholesterolemia
چکیده انگلیسی

ObjectiveTo review the efficacy of ezetimibe monotherapy for treatment of hypercholesterolemia in pediatric patients.Study designThis is a retrospective review of all pediatric patients who received ezetimibe monotherapy as treatment for hypercholesterolemia and for whom follow-up clinical and lipid results were available. Of 36 identified patients, 26 had lipoprotein profiles suggestive of familial hypercholesterolemia (FH), and 10 had profiles suggestive of familial combined hyperlipidemia (FCHL).ResultsAfter a mean 105 days of treatment with ezetimibe (range, 32-175 days), total cholesterol (TC) levels decreased from 7.3 ± 1.0 mmol/L to 5.7 ± 1.0 mmol/L (P < .0001), and low-density lipoprotein cholesterol (LDL-C) levels decreased from 5.3 ± 0.9 mmol/L to 3.9 ± 0.8 (P < .0001) in patients with FH. In patients with FCHL, TC levels decreased from 6.4 ± 2.0 mmol/L to 5.6 ± 0.4 mmol/L (P ≤ .002), and LDL-C levels decreased from 4.7 ± 1.0 mmol/L to 3.8 ± 0.6 mmol/L (P ≤ .005). For all patients, the mean decrease in individual LDL-C values was 1.5 ± 0.9 mmol/L or 28%. There was no significant change in triglyceride or high-density lipoprotein cholesterol levels with ezetimibe. Patients were maintained on ezetimibe with no adverse effects attributable to the medication for as long as 3.5 years. At a mean of 13.6 months (range, 1-44 months) after the initiation of ezetimibe, LDL-C levels remained decreased at 4.0 ± 0.6 mmol/L.ConclusionsIn this small retrospective series of children and adolescents with hypercholesterolemia, ezetimibe was safe and effective in lowering LDL-C levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 154, Issue 6, June 2009, Pages 869–872
نویسندگان
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