کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4167228 1607535 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fatty Acid Ethyl Esters in Meconium are Associated with Poorer Neurodevelopmental Outcomes to Two Years of Age
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Fatty Acid Ethyl Esters in Meconium are Associated with Poorer Neurodevelopmental Outcomes to Two Years of Age
چکیده انگلیسی

ObjectiveTo determine the relationship between fatty acid ethyl esters (FAEE) in meconium and neurodevelopment in infants exposed to alcohol in utero at 6.5 months, 1 year, and 2 years of age.Study designA secondary analysis of a prospective cohort of mothers at high risk and their infants recruited after admission to a labor and delivery unit. Mothers were screened for drug and alcohol use during pregnancy by clinical interview and urine screening. Meconium was analyzed for FAEE in 216 newborn infants. Outcome measures included the Bayley Scales of Infant Development Mental (MDI) and Psychomotor (PDI) Developmental Index scores in infants at 6.5 months, 1 year, and 2 years of age.ResultsAfter controlling for prenatal visits and maternal factors, increasing concentrations of FAEE were significantly associated with poorer mental and psychomotor development (β ± standard error) at all follow-up visits: ethyl myristate (MDI −2.46 ± 1.24, P = .05; PDI −3.88 ± 1.67, P = .02), ethyl oleate (MDI −1.94 ± 0.65, P < .01; PDI −2.60 ± 0.93, P < .01), ethyl linoleate (MDI −1.92 ± 0.60, P < .01; PDI −2.28 ± 0.84, P < .01), ethyl linolenate (MDI −1.99 ± 0.74, P < .01; PDI −2.98 ± 1.04, P < .01), and ethyl arachidonate (MDI −2.40 ± 1.11, P = .03; PDI −3.32 ± 1.51, P = .03).ConclusionFAEE in meconium may be a marker for identifying newborns at risk for neurodevelopmental delay from alcohol exposure in utero.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 152, Issue 6, June 2008, Pages 788–792
نویسندگان
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