کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
416751 681398 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Classification of pathological stage of prostate cancer patients using penalized splines
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر نظریه محاسباتی و ریاضیات
پیش نمایش صفحه اول مقاله
Classification of pathological stage of prostate cancer patients using penalized splines
چکیده انگلیسی

We propose a penalized splines (P-splines) based method to predict the pathological stage of localized prostate cancer. A combination of prostate-specific antigen, Gleason histological score, and clinical stage from a cohort study of 834 prostate cancer patients are used to build the P-splines model. It turns out that the proposed methodology results in improved prediction of pathological stage compared to usual logistic regression after removing a few outliers. The improvement is shown to be statistically significant. Receiver-operating characteristic (ROC) curve is drawn and we show that the increase in area under the ROC curve over the commonly used logistic regression based classification method is also statistically significant.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computational Statistics & Data Analysis - Volume 51, Issue 2, 15 November 2006, Pages 1147–1155
نویسندگان
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