کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4167525 | 1607536 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Double-blind Placebo-Controlled Trial of Amitriptyline for the Treatment of Irritable Bowel Syndrome in Adolescents Double-blind Placebo-Controlled Trial of Amitriptyline for the Treatment of Irritable Bowel Syndrome in Adolescents](/preview/png/4167525.png)
ObjectivesTo determine the efficacy of amitriptyline (AMI) in treating irritable bowel syndrome (IBS) in adolescents.Study designAdolescents 12 to 18 years with newly diagnosed IBS were surveyed with a symptom checklist, pain rating scale, visual analog scale, and IBS quality of life (QOL) questionnaire. Subjects were randomized in a double-blinded fashion to receive AMI or placebo, and again completed surveys at 2, 6, 10, and 13 weeks.ResultsThirty-three patients (24 female) were enrolled. Patients receiving AMI were more likely to experience improvement from baseline in overall QOL at 6, 10, and 13 weeks (P = .019, .004, and .013). Patients receiving AMI were also more likely to experience a reduction in IBS-associated diarrhea at 6 and 10 weeks (P = .029 for both), a reduction in periumbilical pain at 10 weeks (P = .018), and a reduction in right lower quadrant pain at 6, 10, and 13 weeks (P = .014, .039, and .004).ConclusionAMI significantly improves overall QOL in adolescents with IBS and should be a therapeutic option for adolescents with this disorder.
Journal: The Journal of Pediatrics - Volume 152, Issue 5, May 2008, Pages 685–689