کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4167797 1607538 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Growth Hormone Treatment and Fat Redistribution in Children Born Small for Gestational Age
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Growth Hormone Treatment and Fat Redistribution in Children Born Small for Gestational Age
چکیده انگلیسی

ObjectiveTo determine whether in children born small for gestational age (SGA) high-dose growth hormone (GH) treatment is not only associated with catch-up of growth and with gain of lean mass, but also with a more central fat distribution.Study designShort children who were SGA (n = 25; age [mean ± SD], 5.3 ± 1.5 years) were randomly assigned to remain untreated (n = 14) or to receive GH (n = 11; sc 66 μg/Kg/d). Growth status and body composition were assessed at the study’s start, after 1 year, and after 2 years with anthropometry and absorptiometry.ResultsChildren who were treated with GH gained more height and weight than children who were untreated and developed a less adipose body composition (all P < .0001), as expected. However, these changes were also accompanied by a relatively more centripetal distribution of fat mass (0-2 year change in ratio of trunk fat to limb fat; 0.26 ± 0.23 versus 0.02 ± 0.15; P < .0001).ConclusionIn children who are SGA, catch-up growth induced by exogenous GH in high doses is accompanied by a less adipose body composition and a more central fat distribution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 152, Issue 3, March 2008, Pages 327–330
نویسندگان
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