کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4168483 1607546 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Risk Factors for Development of Subclinical Hypothyroidism during Valproic Acid Therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
پیش نمایش صفحه اول مقاله
Risk Factors for Development of Subclinical Hypothyroidism during Valproic Acid Therapy
چکیده انگلیسی

ObjectiveTo identify risk factors for subclinical hypothyroidism (SCH) (thyroid-stimulating hormone levels >5 mIU/mL) in patients receiving valproate (VPA) therapy.Study designDuring a period of 2 years, consecutive patients with epilepsy receiving VPA and a control group of patients with diseases other than epilepsy attending a tertiary care neurology clinic were screened for SCH. The 2 groups were compared. The association between SCH and specific risk factors was investigated with bivariate and multivariate analyses.ResultsThirty-six of 143 patients receiving VPA (25.2%, mean age ± SD: 8.5 ± 6.6 years) and none of the 35 control subjects had SCH (P < .001). Predictors of SCH were younger age (OR: 1.15, cutoff age 3.9 years); duration of treatment between 6 and 24 months versus <6 months (OR: 2.98) and >24 months (OR: 2.66); VPA polytherapy with enzyme-inducing agents (OR: 6.08), or polytherapy with non-enzyme-inducing agents (OR: 3.34) compared with VPA monotherapy. Most (88.2%) patients with duration of therapy >2 years were older than 3.9 years.ConclusionRisk factors for SCH were young age, co-medication with antiepileptic drugs, and duration of therapy between 6 and 24 months. Screening patients with these risk factors may be warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Pediatrics - Volume 151, Issue 2, August 2007, Pages 178–181
نویسندگان
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