کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4169233 | 1607560 | 2006 | 4 صفحه PDF | دانلود رایگان |
ObjectivesTo determine whether acute left ventricular dysfunction (LVD) causes significantly higher elevation of N-terminal pro-B–type natriuretic peptide (NT-proBNP) levels than comparable chronic LVD.Study designPlasma levels of NT-proBNP were measured in 10 pediatric patients diagnosed with acute LVD, in 7 pediatric patients with stable chronic dilated cardiomyopathy (DCM) and comparable levels of echocardiographic dysfunction, and during 5 episodes of acute exacerbation in patients with heart failure. Levels were compared using Mann-Whitney and analysis of variance for rank tests.ResultsPlasma levels of NT-proBNP were excessively elevated in patients with acute LVD in the first 24 to 48 hours of hospitalization (median level, 65,600 pg/mL), and were significantly higher than those in patients with chronic DCM (median level, 1125 pg/mL; P < .0001). NT-proBNP levels decreased in the subsequent days in 83% of patients with serial measurements. The NT-proBNP levels were lower In 5 episodes of acute exacerbation than in acute LVD (median level, 7185 pg/mL; P < .003).ConclusionsAcute LVD is associated with elevated NT-proBNP level in children.
Journal: The Journal of Pediatrics - Volume 149, Issue 1, July 2006, Pages 28–31