Congenital anomalies of the esophagus

Congenital malformations of the esophagus are frequently encountered by pediatric surgeons, especially esophageal atresia with or without tracheo-esophageal fistula. However, the molecular mechanisms underlying the development of these various anomalies are not clear. Here we present a brief overview of the embryologic development of the tracheoesophageal tube, along with some of the genetic controls which, when defective can lead to abnormal separation of this tube.