The Ritter reaction under incredibly green protocol: Nano magnetically silica-supported Brønsted acid catalyst

HClO4-functionalized silica-coated magnetic nanoparticles [γ-Fe2O3@SiO2-HClO4] (2.5 mol%) has been found to be a capable biocompatible and recyclable catalyst for highly efficient conversion of a variety of alcohols to corresponding amides via modified Ritter reaction in good to excellent yields. Since this heterogeneous catalyst can be simply removed by using an external magnetic device then recovered, it also enhances product purity and promises economic.

Figure optionsDownload high-quality image (43 K)Download as PowerPoint slideResearch highlights▶ Magnetically recoverable catalyst leading to enhancement simplicity and product purity. ▶ Capable biocompatible and green catalyst. ▶ Mild, cost-effective and applicable efficient reusable heterogeneous catalyst. ▶ Economically and environmentally benign procedure for synthesis of amides from alcohols.