کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4195671 | 1278627 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells
ترجمه فارسی عنوان
پلی فنولهای چای سبز از مهار وریدهای ناشی از گلوکز بالا در سلولهای اندوتلیال جلوگیری می کند
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی
Bovine aortic endothelial cells (BAECs) were cultured with high glucose (33 mmol/L), 4 mg/L green tea polyphenols (GTPs) or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1 (BAF). We observed that high glucose increased the accumulation of LC3-II. Treatment with BAF did not further increase the accumulation of LC3-II. Results also showed an increased level of p62 and decreased Beclin-1. However, GTPs showed inversed trends of those proteins. Furthermore, GTPs co-treatment with high glucose decreased the level of LC3-II and a much higher accumulation of LC3-II was observed in the presence of BAF in comparison with high glucose alone. Results also showed a decreased p62 and increased Beclin-1. The results demonstrated that GTPs alleviated autophagy inhibition induced by high glucose, which may be involved in the endothelial protective effects of green tea against hyperglycemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 29, Issue 7, July 2016, Pages 524-528
Journal: Biomedical and Environmental Sciences - Volume 29, Issue 7, July 2016, Pages 524-528
نویسندگان
Pi Wei ZHANG, Chong TIAN, Fang Yi XU, Zhuo CHEN, Raynard BURNSIDE, Wei Jie YI, Si Yun XIANG, Xiao XIE, Nan Nan WU, Hui YANG, Na Na ZHAO, Xiao Lei YE, Chen Jiang YING,