کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4195788 1278637 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flexibility Analysis of Bacillus thuringiensis Cry1Aa
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Flexibility Analysis of Bacillus thuringiensis Cry1Aa
چکیده انگلیسی

ObjectiveTo investigate the flexibility and mobility of the Bacillus thuringiensis toxin Cry1Aa.MethodsThe graph theory-based program Constraint Network Analysis and normal mode-based program NMsim were used to analyze the global and local flexibility indices as well as the fluctuation of individual residues in detail.ResultsThe decrease in Cry1Aa network rigidity with the increase of temperature was evident. Two phase transition points in which the Cry1Aa structure lost rigidity during the thermal simulation were identified. Two rigid clusters were found in domains I and II. Weak spots were found in C-terminal domain III. Several flexible regions were found in all three domains; the largest residue fluctuation was present in the apical loop2 of domain II.ConclusionAlthough several flexible regions could be found in all the three domains, the most flexible regions were in the apical loops of domain II.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 28, Issue 9, September 2015, Pages 634-641