کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4195959 1278649 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses
چکیده انگلیسی

ObjectiveWe examined alterations in the expression of tumorigenesis-related genes in the pituitary gland of rats exposed to electromagnetic pulses (EMP).MethodsThe global gene expression profiles of the pituitary gland in EMP-exposed and control groups were detected by cDNA microarray analysis. We then validated and further investigated the reduced expression of two tumorigenesis-related genes, Pten, and Jund, by assessing their mRNA and protein expression by quantitative real-time-PCR, western blotting, and immunohistochemistry in the pituitary gland of rats 6 months after exposure to EMP.ResultsEMP exposure induced genome-wide gene expression changes in the rat pituitary gland. There was decreased expression of the Pten and Jund mRNAs and proteins in EMP-exposed rats compared with in unexposed control animals.ConclusionEMP exposure alters the expression of tumorigenesis-related genes in the pituitary gland. These tumorigenesis-related genes are potentially involved in the development of pituitary gland tumors in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 24, Issue 5, October 2011, Pages 560-568