کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4196305 1278673 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunological Effect of PM2.5 on Cytokine Production in Female Wistar Rats1
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Immunological Effect of PM2.5 on Cytokine Production in Female Wistar Rats1
چکیده انگلیسی

ObjectiveTo investigate the immunological effect of PM2.5 on cytokine production in female Wistar rats.MethodsFemale Wistar rats were given 0.3 mg, 0.75 mg, 2 mg, 5 mg of PM2.5 per 0.5 mL saline, respectively. Saline was used as the negative control. TNF-α and IL-6 levels in the branchoalveolar lavage were measured by ELISA, and mRNA expression levels in lung tissue were detected by RT-PCR. Alveolar macrophages were collected for testing phogacytic function.ResultsExposure to PM2.5 stimulated TNF-α production in a dose-dependent manner (P < 0.05), However, no statistically significant difference was found. No time-dependent change in TNF-α and IL-6 production was found. TNF-α and IL-6 mRNA expressions were induced by PM2.5-exposure. The phagocytic rate (PR) was significantly decreased by PM2.5 treatment.ConclusionPM2.5 exposure increases inflammation response of the lung in a dose-dependent manner. Moreover, tissue injury induced by PM2.5 may be related to altered production of cytokines. PM2.5 may impair the phagocytic activity of alveolar macrophages.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedical and Environmental Sciences - Volume 21, Issue 1, February 2008, Pages 63-68