کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4200991 1279384 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of catgut implantation at acupoints on leptin and insulin resistance in simple obesity rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
Influence of catgut implantation at acupoints on leptin and insulin resistance in simple obesity rats
چکیده انگلیسی

ObjectivesTo investigate the influence of catgut implantation at acupoints on leptin resistance (LR) and insulin resistance (IR) in the simple obesity rat.MethodsRats were made obese with high-fat diets, after which surgical catgut was implanted at Zusanli (ST 36) and Neiting (ST 44) acupoints once a week for 4 weeks (implantation group). Rats from the implantation group were compared with normal rats and unoperated obese rats (control group). Gene expression of the leptin receptor (OB-R) was evaluated using RT-PCR and northern blot. Serum and hypothalamus leptin and insulin (INS) levels were determined by radioimmunoassay. Body weight, Lee's index, body fat, serum and hypothalamus leptin and INS levels, and hypothalamic OB-R gene expression were determined before and after treatment.ResultsBody weights, Lee's index, body fat, and serum leptin and INS levels were significantly higher in obese than in normal rats. Hypothalamic leptin and INS levels and OB-R gene expression were significantly lower in obese rats. Catgut implantation at acupoint promoted weight loss and decreased serum leptin and INS levels. Hypothalamic leptin and INS levels and OB-R gene expression increased significantly.ConclusionsCatgut implantation at acupoint adjusts central and peripheral leptin and promotes hypothalamic OB-R gene expression. This may be an important method for regulation of LR, IR and abnormal endocrinology and metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Traditional Chinese Medicine - Volume 32, Issue 3, September 2012, Pages 477-481