کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4201357 | 1279401 | 2012 | 6 صفحه PDF | دانلود رایگان |
ObjectiveTo investigate plasma samples from neoplasm patients with phlegm-stasis or abnormal Savda syndrome, with NMR spectroscopy, and to analyze their metabolic varieties, characteristics and reciprocity.Methods1H-NMR spectra were analyzed using the orthogonal projection to latent structure with discriminative analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of metabolites was determined by the Pearson's product–moment correlation coefficient.ResultsCompared to the control group, neoplasm patients with phlegm – stasis or abnormal Savda syndrome had low concentrations of leucine, isoleucine, valine, alanine, tyrosine, histidine, citrulline, glycoprotein, glutamine, myo-inositol, scyllo-inositol, creatine, α-glucose, β-glucose and lactate (P<0.05), and high concentrations of very low density lipoprotein, low density lipoprotein, unsaturated lipid, formate, acetone, acetate, acetoacetate, pyruvate, β-hydroxybutyrate, carnitine and malonic acid (P<0.05), with no significant differences between the phlegm – stasis and abnormal Savda syndrome patients.ConclusionsNeoplasm patients with different syndromes have very similar metabolic changes. A series of abnormalities such as immune dysfunction and oxidative – antioxidative imbalance, occur in neoplasm patients with abnormal Savda or phlegm – stasis syndrome.
Journal: Journal of Traditional Chinese Medicine - Volume 32, Issue 1, March 2012, Pages 119-124